The reference site for Sulpiride

Sulpiride is an atypical antipsychotic drug  of the benzamide class used mainly in the treatment of psychosis associated with schizophrenia and major depressive disorder.

WHAT IS Sulpiride?

Sulpiride is a selective dopamine D2 antagonist drug used mainly in the treatment of psychosis (e.g. schizophrenia) and depression. It is sometimes referred to as a ‘major tranquilliser’, and works by blocking dopamine receptors in the brain.

This medication has strong chemical and clinical similarities to the novel anti-psychotic amisulpride, and is a substituted benzamide.

Sulpiride is more commonly used in Europe and Japan, and has currently not been approved for use in the US and Canada. Nevertheless, this medication is sold under numerous brand names including Bosnyl®, Dogmatil®Dolmatil®, Eglonyl®, Meresa®Sulpor®, and Sulpitil®.


Brand Name(s): Bosnyl; Dogmatil; Dogmil; Dolmatil; Eglonyl; Sulpitil; Sulpor; Sulparex; Meresa
CAS nº: 15676-16-1
(sul pee ride)


Product Info

The sections below will provide you with more specific information and guidelines related to sulpiride and its correct use. Please read them carefully.

FDA Information

Sulpiride is more commonly used in Europe and Japan, and has currently not received FDA approval in the US and Canada.

A prescription is required for this medicine.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Sulpiride is a selective dopamine D2 antagonist (and also a substituted benzamide neuroleptic), which is used as an antipsychotic and also as an antidepressant/anxiolytic in some countries.

Like all antipsychotic drugs, sulpiride is thought to work by blocking dopamine receptors in the brain, and works by exerting antipsychotic action, antiemetic actions and an effect on gastrin secretion.

Additionally, sulpiride is effective in the treatment of acute and chronic schizophrenia but does not appear to offer a significant advantage over other antipsychotic agents.

Mechanism of action:

Sulpiride acts by blocking a variety of receptors in the brain, particularly dopamine receptors. Dopamine is involved in transmitting signals between brain cells. When there is an excess amount of dopamine in the brain it causes over-stimulation of dopamine receptors. These receptors normally act to modify behaviour and over-stimulation may result in psychotic illness. Sulpiride blocks these receptors and stops them becoming over-stimulated, thereby helping to control psychotic illness’s such as schizophrenia.

Other uses for this medicine

Other possible therapeutic uses of sulpiride that are currently under investigation include:

A combination of sulpiride and norethindrone was reported more effective than norethindrone alone in suppressing urinary excretion of estrone and pregnanediol in one small study. It was suggested that the combination may improve contraception by virtue of mimicking lactation secondary to sulpiride-induced increases in prolactin secretion. The use of sulpiride in this manner has been criticized due to its potential to produce tardive dyskinesia and because combination oral contraceptives are highly effective. Other investigators suggest that increasing the dose of progestogen alone would achieve the same effect as combined sulpiride therapy.

Duodenal Ulcer:
Oral sulpiride 50 to 100 mg 3 times daily was reported to enhance the efficacy of antacids (aluminum-magnesium hydroxide) on duodenal ulcer healing in a controlled study. In another study, duodenal ulcer recurrence rates were healed with a combination of sulpiride (200 mg daily) plus cimetidine (800 mg daily) as compared with cimetidine alone. Further studies are required to assess the potential role of sulpiride in Peptic Ulcer disease, including comparisons with bismuth subsalicylate or colloidal bismuth subcitrate regimens.

Huntington’s Disease:

Oral sulpiride has reduced abnormal movements in patients with Huntington’s disease. However, no functional improvement was observed.

Inadequate Lactation:
Oral sulpiride 50 mg two or three times daily for 4 days to 4 weeks has increased serum prolactin levels and enhanced breast milk yield in puerperal women with inadequate lactation. In one study, efficacy was observed in primiparous but not multiparous mothers; this was attributed to spontaneous increases in milk secretion in the multiparous group without medication. Further investigations are needed before sulpiride can be recommended for improving lactation, including potential neonatal endocrinogical effects. Some investigators suggest that simply increasing the frequency of nursing is the best stimulus to inadequate lactation.

Sulpiride 150 to 300 mg daily has been reported effective in the treatment of neurotic disorders, with symptoms of anxiety, mixed anxiety-depression, tension, obsessions, and hypochondriasis, in limited double-blind studies. In these studies, however, sulpiride offered no apparent advantage over chlordiazepoxide or diazepam. Diazepam was superior to sulpiride with regard to alleviation of psychic anxiety in one trial.

Tardive Dyskinesia:

Due to a potential lower tendency to induce extrapyramidal disorders by virtue of selective dopamine D2 receptor antagonism, oral sulpiride has been used as an alternative to phenothiazines and butyrophenones to suppress tardive dyskinesia symptoms. In limited studies, sulpiride 200 to 1200 mg daily has been effective in reducing movement abnormalities in patients which tardive dyskinesia. However, parkinsonian symptoms (which were intended to be avoided) occurred in 30% to 75% of these patients; an increase in tardive dyskinesia symptoms was also observed occasionally with institution of sulpiride therapy. Recently, several reports of tardive dyskinesia and tardive dystonia attributed to sulpiride therapy of anxiety, depression, and gastrointestinal symptoms have been described. Until further is known regarding the propensity of the drug to induce tardive dyskinesia, its use for the treatment of this disorder is not recommended.

Tourette’s Disorder:

Oral sulpiride 200 to 1000 mg daily was reported beneficial in the treatment of Gilles de la Tourette syndrome in a retrospective study. Reductions in the frequency or severity of vocal or motor tics, obsessional behavior, and aggression were observed. A controlled study comparing sulpiride with haloperidol is needed to determine if sulpiride will have a role in this disorder.

Dosage and using this medicine

Sulpiride is available in tablet and oral solution form.

Take sulpiride exactly as directed by your doctor. Moreover, always read the manufacturer’s information leaflet, if possible, before beginning treatment.

Try to get into the habit of taking sulpiride at the same times each day to avoid missing any doses.

You may have to take sulpiride for several weeks before you feel the full effect.

Do not stop taking sulpiride without first speaking with your doctor. Your doctor will probably want to reduce the dose you are taking gradually, as stopping treatment suddenly can cause problems.

Never take more than the prescribed dose. If you suspect that you or someone else has taken an overdose of sulpiride contact your doctor or go to the accident and emergency department of your local hospital immediately. Always take the container with you, if possible, even if it is empty.

This medicine is for you. Never give it to others even if their condition appears to be the same as yours.

What special precautions should I follow?


Please inform your doctor as soon as possible of the following: if you are pregnant, trying for a baby or breast-feeding; if you suffer from any heart problems; if you suffer from liver, kidney or breathing problems; if you suffer from Parkinson’s disease; epilepsy; depression; myasthenia gravis (a muscle weakening disease); prostate problems; porphyria (a blood disorder); phaeochromocytoma (a growth on the adrenal glands) or glaucoma; if you suffer from postural hypotension (if you become dizzy when getting up from a sitting or lying position); if you have ever had an allergic reaction to this or any other medicine; if you are taking any other medicines, including those available to buy without a prescription, herbal and complementary medicines. You may not be able to take sulpiride, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Moreover, tell your doctor if you are taking any of the following drugs: levodopa, antihypertensive agents, or other central depressants. You may not be able to take sulpiride, or you may require a dosage adjustment or special monitoring during treatment if you are taking any kind of the medicines listed above.

Keep your regular appointments with your doctor, so your progress can be checked.

Sulpiride can cause drowsiness, dizziness and blurred vision. Make sure you know how you react to sulpiride before driving, operating machinery or doing any other jobs which could be dangerous if you were not fully alert or able to see properly.

Alcohol will increase feelings of drowsiness. If you do drink alcohol, drink only in moderation and be aware of its effects on you.

Before having any surgery, including dental or emergency treatment, tell the surgeon, doctor or dentist that you are taking Sulpiride.

Additionally, sulpiride can occasionally cause a dry mouth. If you experience this, try chewing sugar-free gum, sucking sugar-free sweets or pieces of ice. If a dry mouth becomes too troublesome discuss the problem with your doctor or pharmacist.

Sulpiride can cause some people’s skin to become more sensitive to sunlight than it usually is. Try to avoid the sun and sunbeds until you know how your skin reacts or use a suncream higher than factor 15.

What should I do if I forget a dose?

If you miss a dose, take it as soon as you remember. However, if it is nearly time for your next dose, just take that one as normal and tell your doctor that you missed one.

Never attempt to make up for your missed dose by taking extra medication or doubling up as this can cause serious side effects.

What side effects can this medication cause?

Along with its useful effects sulpiride can cause unwanted side effects, which usually improve as your body adjusts to it. Speak with your doctor if any of the following side effects continue or become troublesome:

shakiness or restlesness
abnormal face and body movements
uncontrollable movements of the tongue face and jaw
drowsiness, dizziness or confusion
mood changes
insomnia (trouble sleeping)
a headache
constipation, diarrhoea, or tummy ache
a stuffy nose
dry mouth
problems urinating (passing water)
blurred vision
a fast or thumping heartbeat
changes in menstruation (periods) or breast problems
sexual problems
weight gain
skin rashes
jaundice (yellowing of the skin and whites of the eyes) or a purple tint to the skin and eyes

IMPORTANT: If you experience ‘flu like’ symptoms such as stiffness, high temperature, abnormal paleness, leaking bladder or a racing heartbeat, contact your doctor or go to the accident and emergency department of your local hospital immediately.

If you experience any other worrying symptoms, which you think may be due to sulpiride, discuss them with your doctor or pharmacist.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Please remember to throw away any medication that is outdated or no longer needed. If you have any questions regarding the proper disposal of your medication then talk to your pharmacist.

In case of an emergency/overdose

In the case of a suspected overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing,  then please call the local emergency services straight away on 911.

Symptoms of overdose may include:

cardiac arrhythmias

Product Images


Below you will find images and specific information on the principal types of sulpiride that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Strength(s): 50 MG
Imprint: EGLONYL
(Under license from SANOFI-SYNTHELABO)

Strength(s): 100 MG / 2 ML
Imprint: EGLONYL
(Under license from SANOFI-SYNTHELABO)

Strength(s): 100 MG / 2 ML
Imprint: EGLONYL
(Under license from SANOFI-SYNTHELABO)

Strength(s): 200 MG
(Under license from SANOFI-SYNTHELABO)

Strength(s): 200 MG
Imprint: DOGMIL

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